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Keywords: GHK-Cu, acute lung, injury, inflammation, NF-κB p65, p38 MAPK INTRODUCTION Acute lung injury (ALI), along with its most severe form, acute respiratory distress syndrome (ARDS), is a disorder of acute inflammation and tissue injury that is characterized by the loss of alveolar-capillary membrane integrity, excessive transepithelial neutrophil migration, and the release of pro-inflammatory and cytotoxic mediators [1, 2]